No Start / Crank No Fire - Loose Main EFI Relay Terminal Connectors
Car cranks but does not start - no fuel pump activation and no spark. The Main EFI Relay was not being energized by the M-REL signal from the ECU. A previous owner had installed a jumper wire from the IGN fuse to pin 1 of the Main EFI Relay as a workaround, which masked the real problem and eventually fried the AEM V-1 aftermarket ECU's M-REL output.
The female pin connectors inside the Main EFI Relay terminal socket (in the fuse box) had become loose and were not making solid contact with the relay pins. This caused the M-REL 12V trigger signal from the ECU to not reach the relay coil with enough voltage to energize it, even though the Black/Orange wire tested good end-to-end when unloaded.
High confidence — Original poster confirmed this resolved the issue